Frontiers in Chemistry

Organic Chemistry Frontiers Highlight

This highlight discusses developments in transition metal-catalysed alkene and alkyne hydroacylation reactions over the past three years. The discussion summarizes the development of new catalyst systems for alkene and alkyne hydroacylation and applications to the synthesis of important ketone building blocks. The highlight captures transition metal-catalysed alkene and alkyne hydroacylation at...

"Frontiers of Vibrational Spectroscopy in Analytical Chemistry".

Frontiers in chemistry grand challenge: open communication to the world

The excitement of making a new compound, discovering new characterization methods, and applying these systems for practical applications is a feeling that many of us as chemists and scientists markedly enjoy. Yet how can we pass along these experiences to younger generations? One major way involves communication of our results in written forms that others can experience over long periods of tim...

The 10th Annual Frontiers in Chemistry and Biology Interface

Multi-domain proteins often require help from molecular chaperones to fold productively, even before the ribosome has finished their synthesis. The mechanisms underlying chaperone function remain poorly understood. Using optical tweezers to study the folding of elongation factor G (EF-G), a model multi-domain protein, we find that the N-terminal G-domain in nascent EF-G polypeptides folds robus...

New frontiers in host-guest chemistry: The gas phase

Aspects of host-guest complexation are examined in the solvent-free environment of a mass spectrometer. A kinetic dissociation method is used to determine orders of relative ammonium and alkali metal cation binding affinities of an array of model hosts, such as crown ethers and their acyclic analogs. Sizeselective effects on binding are observed from these gas-phase experiments. The binding pro...